Current Issue Cover

Current issue

Vol 136 / Issue 24

  • Coming soon in Development

    • Repairing DNA demethylation

      DNA demethylation in Arabidopsis involves the DNA glycolase DEMETER, which activates the maternal allele of imprinted genes by removing methylated cytosines. In doing so, it causes DNA single-stand breaks, which Berger and colleagues now report are repaired by the housekeeping gene DNA LIGASE 1.

    • Elusive fly stem cell found

      Minakhina and Steward report in this issue the first discovery of hematopoietic stem cells (HSCs) in Drosophila, which they found in the lymph glands of embryos and young larvae and which require the conserved factor Zfrp8/PDCD2 for their maintenance.

    • Long range Shh dispatched

      Roelink and colleagues shed light on how the insoluble mature Shh protein signals over a long range. Not by long-range diffusion, they report, but by Dispatched1-dependent Shh secretion coupled to Patch1-dependent Shh uptake, which together ensure its long-range distribution.

  • Featured movie

    C .elegans sad-1 mutant. More on SAD-1 in neuronal polarity and synaptic organization is coming in Issue 1.