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Fig. 5. Fgf8 and Fgf3 induce spry4. (A-D) Lateral view of gastrula stage embryos stained for spry4. Dorsal is towards the right. (A) Wild type. (B,C) Widespread overexpression of Fgf3 or Fgf8 induces spry4 throughout the embryo. (D) Microinjection of fgf8 mRNA in one central blastomere of a 16-cell stage embryo induces spry4 at the animal pole, far from its endogenous expression domain. (E,F) Implantation of Fgf8-secreting beads induces spry4 expression. Lateral view (E) and dorsal close-up, anterior towards the left.