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Fig. 4. Downregulation of Hoxa1 in BMS493-treated embryos. Dorsal view of whole mounts of control (a) and antagonist-treated (5x10-6 M) chick embryos at stage 4 (b). Note the downregulation of Hoxa1 in its anterior domain of expression in b. Arrows indicate the normal rostral limit of Hoxa1 expression.