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Fig. 1. Amino acid sequence homology between XLMO-2 and the mouse, human and zebrafish homologs. (A) Pile-up analysis of the LMO-2 protein sequences reveals extensive sequence identity between vertebrate LMO-2 proteins. Accession Numbers for sequences used in this comparison: human (hLMO-2, NM_005574; Boehm et al., 1991), mouse (mLMO-2, NM_008505; Boehm et al., 1991) and zebrafish (zLMO-2, AF191560; Thompson et al., 1998). (B) A phylogenetic tree of the LIM-only proteins shows the close relationship of the vertebrate LMO-2 proteins.