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Fig. 7. Requirement of the {alpha}vß3 integrin for the potentiation by TN-C of PDGF mitogenic effects. Rat OP cells were plated on PDL substrata or on PDL substrata with exogenous purified TN-C (PDL+TN-C) in the presence (F11(+)) or absence (F11(-)) of a ß3 function-blocking monoclonal antibody. Cells were then grown in the presence of different concentrations of PDGF (1, 4, 7, 10: 0 ng/ml; 2, 5, 8, 11: 1 ng/ml; 3, 6, 9, 12: 10 ng/ml) for 18 hours before the addition of BrdU for 6 hours. Results represent mean±s.e.m. of three independent experiments (Student’s t test: *P<0.001, comparison between PDL and PDL+ TN-C; °P<0.001, comparison between F11(+) and F11(-)).