Fig. 1. egl-38 and lin-48 affect the development of cells in the middle region of the C. elegans hindgut (indicated with a shaded box). (A) Wild-type pattern of hindgut cell types. (B) In egl-38 mutants, the presumptive F and U cells develop like their posterior neighbors, B and Y (Chamberlin et al., 1997). The presumptive K' cell can develop like its sibling and neighbor, K. (C) In lin-48 mutants, the presumptive U cell can develop like its neighbor and lineal homolog, B. The presumptive F cell develops abnormally (asterisk; Chamberlin et al., 1999). The presumptive K' cell can develop like its sibling and neighbor, K. Int, intestine; irv, intestinal rectal valve cells (also called vir); rep, rectal epithelial cells. Anterior is towards the left, dorsal is upwards.