Fig. 2. Deformations and changes of patterning genes in mandibular arch of E10.5 embryos. (A) Prx2 expression in Prx2^+/- embryo visualized by ß-galactosidase staining (blue). In situ hybridization with Dlx2 (B,C) and Alx3 (D,E) probes on nearby sections of wild-type (B,D) and Prx1^-/-Prx2^-/- (C,E) embryos. Expression is indicated in red. Owing to small differences in stage and orientation of embryos, sections at comparable levels do differ in shape and size. (F,G) The shift of the expression domains of Dlx2 and Alx3 in Prx1^-/-Prx2^-/- embryos (G) compared with wild-type embryos (F). Arrows in C,E indicate abnormal epithelium. Dorsal is upwards.