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Fig. 5. Effects of jervine on lower jaw and limb development. (A) Exposure of embryos to jervine at E9.5 results in truncation of the distal lower jaw and loss of the incisors. Proximal is upwards. (B) Jervine exposure at E9.5 induces oligosyndactyly in the forelimb (left), but mainly carpal fusions in the hindlimb (right).