Development -- Boyl et al. 128 (15): 2989 Figure IG2

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Fig. 2. Morphology of Otx2 ${lambda}$ /Otx2 ${lambda}$ and Otx2 ${lambda}$ /- embryos. (A-J) When compared with wild-type (A,F), Otx2 ${lambda}$ /Otx2 ${lambda}$ embryos exhibited brain abnormalities, the majority of which were exencephaly, lack of closure of neural tube (B,G) or reduction of forebrain-midbrain (C,H); 90% of Otx2 ${lambda}$ /- embryos revealed a severe reduction of anterior CNS with an almost headless phenotype (D,I,J) and 10% of them a phenotype (E) similar to that of Otx2 ${lambda}$ /Otx2 ${lambda}$ mutants. Fb, forebrain; Hb, hindbrain; Mb, midbrain.