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Fig. 5. Pharyngeal pouches and epibranchial placodes develop normally despite the loss of the second arch ncc. Wild-type (a,d), Hoxa1-/- (b,e) and Hoxa1-/-/Hoxb1 3'RARE-/-(c,f) embryos were processed for whole-mount in situ hybridisation with Pax1 (a-c) and Ngn2 (d-f) antisense riboprobes. (a-c) Expression of Pax1 in the first and second pharyngeal pouches (pp1 and pp2 respectively) was not changed in either Hoxa1-/- or Hoxb1 3'RARE-/- embryos (arrows). (d-f) Expression of Ngn2 in the second arch (pa2) geniculate (ge) and more posterior petrosal (pe) and nodose (no) ganglia revealed that their initial stages of development were not affected in either Hoxa1-/- or Hoxa1-/-/Hoxb1 3'RARE-/- embryos (arrows).