Fig. 1. Sequence and chromosomal localization of Sall1. (A) Amino acid sequence alignment of Sall1 and SALL1. Asterisks indicate cystine and histidine residues in zinc-finger motifs. Underline indicates a putative nuclear localization signal. Black triangles are exon-intron boundaries. (B) Sall1 maps in the central region of mouse chromosome 8. Sall1 was placed on mouse chromosome 8 by interspecific backcross analysis. The segregation patterns of Sall1 and flanking genes in 166 backcross animals that were typed for all loci are shown on the left of the figure. For individual pairs of loci, more than 166 animals were typed. Each column represents the chromosome identified in the backcross progeny that was inherited from the (C57BL/6J x M. spretus) F₁ parent. The shaded boxes represent the presence of a C57BL/6J allele and white boxes represent the presence of a M. spretus allele. The number of offspring inheriting each type of chromosome is listed at the bottom of each column. A partial chromosome 8 linkage map showing the location of Sall1 in relation to linked genes is shown on the right of the figure. Recombination distances between loci in centimorgans are shown on the left of the chromosome and the positions of loci in human chromosomes, where known, are shown on the right. GenBank Accession Number for Sall1, AB051409.