Fig. 5. Lesions in mutant Su(z)12 alleles and comparison between Su(z)12 and related proteins in humans and in Arabidopsis. (Top) Schematic representation of the Drosophila malnogaster Su(z)12 (Dm Su(z)12), Homo sapiens Su(z)12 (Hs SU(Z)12, KIAA0160) and Arabidopsis thaliana (At) EMF2 (N. Yoshida, personal communication), VRN2 (A. Gendall, personal communication) and FIS2 (Luo et al., 1999) proteins (white rectangles) with zinc finger (black box) and VEFS box (stippled box). The locations of the molecular lesions in four different Su(z)12 alleles are indicated (see text). Alignment of the zinc fingers (top right) and the VEFS box (below). Identical amino acids that are found in all five proteins are boxed in red and listed below the alignments, similarities are boxed in colors using the code listed below. Bottom: alignment of Drosophila Su(z)12 and human SU(Z)12 amino acid sequences. Note that the two proteins are conserved over the whole length of the protein. The conserved Gly mutated in Su(z)122 is indicated by an arrowhead.