
Fig. 6. dpp duplications rescue gbb lethality and phenotypes associated with gbb null clones. (A,B) Graphs showing rescue of gbb1/gbb4 transheterozygotes (A) and gbb1/gbb1' homozygotes (B) to adulthood (black bars) and to pupal/pharate stage (hatched bars). dpp duplications cannot rescue gbb null larvae to adulthood, but there is a dramatic rescue of larval lethality to pupal/pharate lethality (B). (C-E) Phenotypes associated with clones both mutant for gbb and carrying four copies of dpp. (C) A large posterior clone. Despite the rescue of gbb lethality and small disk phenotypes, additional doses of dpp fail to rescue PCV loss (arrow), even in clones confined to the posterior compartment. (D) High magnification of the wing in C showing the distal tip of L5. A gbb null clone covering this same region would show loss of the distal quarter of L5 (arrow, compare with Fig. 2G), but with four copies of dpp, the vein is rescued to the margin. Anterior clones mutant for gbb and carrying four copies of the dpp gene (E) show rescue of both wing size and loss of L5 (arrow).