Fig. 3. An alignment of the predicted amino acid sequence of CLK-2 with its homologues from S. cerevisiae (Tel2p), A. thaliana (AtCLK-2) and humans (hCLK-2). Sequences were aligned using DNAMAN 4.1 and adjusted by hand. Similarities are shown in red when they include a residue in Tel2p, and in blue when the similarity is among sequences from multicellular organisms only. When CLK-2 is used to initiate a search by Psi-blast (http://www.ncbi.nlm.nih.gov/blast/psiblast.cgi), the algorithm finds five predicted proteins to be similar to CLK-2 and to each other (E-values are given in brackets): the Drosophila protein CG13854 (e-177); the human protein KIAA0683 (e-169); the Arabidopsis protein CAB88328 (>e-177); the S. pombe protein CAB93845 (e-106); and the S. cerevisiae Tel2p (e-105).