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Fig. 6. Ectopic expression of Ttk69 inhibits replication and represses cyclin E. (A) Kr-Gal4-mediated expression of Ttk69 blocks BrdU incorporation in the domain of expression (flanked by arrowheads). Failure to replicate is due to repression of cyclin E. Expression of cyclin E in the wild-type CNS (B) is inhibited by ectopic expression of Ttk69 in heat-shocked hs-ttk69 embryos (C).