Fig. 2. cls phenotype is rescued by ectopic sox10 expression. Wild-type embryos show many large, strongly pigmented melanophores at 48 hpf (A; close-up of anal region in D), while hs>sox10(L142Q)-injected clsm618 mutants (B) show only tiny melanised spots in position of premigratory NCCs (arrowheads). (C,E,F) By contrast, clsm618 embryos injected with hs>sox10 and heat-shocked, show mosaic rescue of melanophores. This embryo showed one rescued melanophore in the dorsal stripe (* in C), two in the ventral stripe (arrows in C; close-up in E) and one on the yolk sac (F). Scale bar: 125 µm in A-C; 70 µm in D-F.