Fig. 3. CSN3 gene structure and the molecular lesion in the fus11-U203 mutant. (A) The genomic structure of the CSN3 gene. The 11 exons are numbered and the protein coding regions of the exons are black. (B) The molecular lesion of the CSN3 gene in the fus11-U203 mutant. The G to A mutation at the end of the intron 9 is indicated. This mutation results in utilization of a cryptic splicing site within intron 9, which results in in-frame termination of the reading frame after two novel amino acids. (C) Diagrams of the wild-type (WT) and mutant version of the CSN3 protein. The two inserted amino acids and the stop codon (asterisk) in the FUS11-U203 are indicated. The leucine zipper and the PCI domains are represented by striped and black boxes respectively. The amino acid positions are labeled on the top.