Fig. 6. UO126 blocks FGF-induced cell multilayering in lens explants. Representative sections of explants cultured for either 3 (C,D) or 5 days (A,B,E,F) with no FGF2 (A,B) or 100 ng/ml of FGF2 (C-F) in the presence of DMSO (A,C,E) or DMSO with UO126 (B,D,F). FGF2 induced a progressive thickening of lens explants over the culture period, as cells elongated and multilayered (C,E). In the presence of UO126, the multilayering could be blocked with cells remaining as a monolayer on the lens capsule (D,F), similar to control explants (A). Abbreviations: ca, lens capsule. Scale bar: 20 µm.