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Fig. 4. Histological examination of tibial development after removal of Hh signaling. Normal hypertrophy of chondrocytes in Cre10; Smon/Smoc embryos at E14.5 and E18.5. Boxed regions shown at a higher magnification to the right. By contrast, Ihh mutants show a delay in hypertrophy at E14.5, and apositional hypertrophy that extends close to the articular surface at E18.5.