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Fig. 8. Promotion of chondrocyte proliferation by ectopic Ihh signaling. (A) BrdU labeling indices in tibial sections of indicated genotypes at E14.5. (B) BrdU labeling reveals enhanced chondrocyte proliferation at E16.5 following ectopic Ihh expression. (C) BrdU labeling indices in E16.5 embryos after ectopic expression of Ihh or Smo* reveals enhanced proliferation within zone 1, the zone with lower proliferative activity in wild-type embryos. H, hypertrophy zone; Whole, entire proliferative zone.