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Fig. 1. mbGrk and secGrk overexpression in somatic tissues lead to Egfr activation. (A) Structure of mbGrk and secGrk. SP, signal peptide; EGF, EGF motif; TM, transmembrane domain; C, cytoplasmic domain. The arrow represents the site where the stop codon was introduced to generate secGrk. (B-J) Phenotypes observed after UAS-mbGrk and UAS-secGrk ectopic expression in somatic tissues. (B) Wild-type egg with its two dorsal appendages. (C) UAS-mbGrk/CY2: overexpression of mbGrk in all the follicular epithelium leads to a weak eggshell dorsalization (78% of the eggs, n=352). (D) UAS-secGrk/CY2: overexpression of secGrk leads to a very strong dorsalized eggshell phenotype (85% of the eggs, n=244). (E-G) Embryonic cuticles from: wild-type (E), UAS-mbGrk/CY2 (F) and UAS-secGrk/CY2 (G) females. (H) Wild-type wing with five longitudinal veins and two crossveins. (I,J) Weak and strong wing vein phenotypes associated with UAS-mbGrk/MS1096 (I) and UAS-secGrk/MS1096 wings (J).