Fig. 5. Size-fractionated heparin oligosaccharides show different potencies for inducing the bypass phenotype. Exposed brains were treated with size-defined heparin oligosaccharides. (A) Size-dependency of heparin oligosaccharides to induce the bypass phenotype. Brains were exposed with 30 µM of size-fractionated bovine lung heparin fragments. (B) Dose-response curves for the bypass phenotype induction with dp6 (filled circles) and dp12 (open circles). Results are expressed as a percentage of total embryos showing the bypass phenotype. Numbers in parentheses indicate total number of embryos.