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Fig. 1. Sequence alignment of zebrafish and mouse Iroquois proteins. (A) Schematic structure of Iro1 and Iro7. HD, homeodomain; IRO, Iro box. (B) Alignment of zebrafish Iro1, Iro3, Iro5 and Iro7 (ziro1, 3, 5 and 7), and mouse Irx1-Irx6 (mIrx1-Irx6) in part of the N-terminal domain and the homeodomain (blue shaded box in A); broken line represents the homeodomain. (C) Alignment of zebrafish and mouse Iro genes in the IRO box domain (green shaded box in A). Brackets in the right margin show orthologs and paralogs with most similarity (B,C). (D) Percentage similarity of amino acids between mouse Irx (MUS IRX1-IRX6) and zebrafish Iro (ZEF Iro1, Iro3, Iro5 and Iro7) proteins in the region shown in B. Each mouse Irx from the IrxA cluster is shown together with its paralog from the IrxB cluster.