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Fig. 3. Stimulation of Edar (dl) expression by activin A in dental epithelium. (A,B) Activin A bead has stimulated Edar expression in the epithelial signaling center, the enamel knot in an E12 whole tooth germ. (C) Edar expression is not induced by activin A in isolated tooth epithelium. (D) BSA control beads did not stimulate Edar expression. Scale bar: 200 µm.