Fig. 5. Expression of Eda (Ta) and Edar (dl) in wild-type and Lef1^–/– embryos. (A,C) Eda is expressed in the skin of E11 and E15 wild-type littermates of Lef1^–/– embryos. (B,D) In the ectoderm of a Lef1^–/– embryo, expression of Eda was almost completely absent. (E,G) Eda transcripts are seen in the epithelium as well as in the hair follicles in E17 and P0 wild-type littermates. (F) Eda transcripts are downregulated in Lef1^–/– skin. (G) In P0, Lef1^–/– skin, faint Eda expression is seen in the hair follicles. (I,J) Edar is expressed throughout the epithelium in E13 wild-type littermates and Lef1^–/– embryos. (K,L) Edar transcripts are upregulated in the hair follicles in E17 wild-type littermates and Lef1^–/– embryos. Scale bar: 100 µm.