Fig. 6. Kidney abnormalities in 18.5 dpc embryos that are associated with the mutation. The outer cortical layer in the mutant embryos (B) is indistinguishable from the controls (A). Note, however, the reduced number of tubuli (asterisk) in the mutants (B). (C-E) Glomerular defects in the mutants are visible in the inner cortex with the glomerular tufts showing mild (D) to severe (E) capillary aneurysms compared with normal appearance (C). Mutant male embryos display a hydronephric kidney with a thin kidney parenchyma (F). (G) Consecutive transverse section of the same animal as shown in F, demonstrating fusion (arrowhead) of the ureter with the vas deferens. Ur, ureter; Vas Def, vas deferens. Scale bars: 100 µm in A,B; 25 µm in C-E; 250 µm in F,G.