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Fig. 5. Ihh signaling activities in periarticular chondrocytes. In situ hybridization for Ihh (B,F,J), Ptc (C,G,K), Pthrp (D,H,L), Hematoxylin and Eosin (A,E,I). (A-D) Pprfl/fl (control), (E-H) Col2-Cre:Pprfl/fl (I-L) Pprd/–. Arrowheads indicate Ptc and Pprp expression in the periarticular region.