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Fig. 4. Alignment of human (Hs-), mouse (Mm-), and zebrafish (Dr-) Acvrl1 proteins. Zebrafish acvrl1 encodes a 499 amino acid protein with significant homology to mammalian Acvrl1 proteins in the C-terminal serine/threonine kinase domain. In contrast, although the ten cysteines common to all type I TGFß receptors are conserved, the rest of the N-terminal ligand binding domain shows little homology. Black arrowhead, Y88Stop mutation in vbgft09e; gray arrowhead, L249F mutation in vbgy6. GenBank accession numbers: Danio rerio acvrl1 mRNA, complete cds; includes noncoding exon 1: AF435024. Danio rerio acvrl1 mRNA, complete cds; no noncoding exon 1: AF435025.