Fig. 4. A-Alk6^DN and EE-1.0-K-Alk6^DN transgenic lenses have a reduced pole-pole dimension. Graph showing a linear regression analysis of the relationship between equator-equator (nasotemporal) and pole-pole dimensions in lens sections taken from wild-type (blue annotation), homozygous A-Alk6^DN (orange annotation) and EE-1.0-K-Alk6^DN (red annotation) transgenic mice. Measurements taken for this analysis were made on the largest coronal lens sections in a given series. The average dimension for each data set is projected to the axes and marked by the colored dot. The equator-equator dimension in wild-type and transgenic mice is minimally different, but the pole-pole dimension between wild-type and either transgenic is. This indicates that the transgenic lenses are more ellipsoid in shape and that primary fiber cell differentiation is reduced.