Fig. 3. Dephrin is expressed during gastrulation and in the embryonic CNS. (A) During gastrulation, Dephrin expression concentrates at the invaginating cephalic furrows (thin arrows) and at the invaginating mesoderm (thick arrow). (B) After germband retraction, expression of Dephrin is restricted to neuronal cell bodies. No protein is detectable on axonal tracts (arrowheads). (C) Expression of DEph, the Eph-like kinase in Drosophila, is restricted to axons and absent from the cell bodies. (D) Expression in muscles (Gal4 line 24B) of the secreted DephrinC-Term, which has an intact receptor binding domain, shows an accumulation of the truncated form (green, -Dephrin) along axons (red, BP102). Horizontal views; anterior to the left.