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Fig. 2. Frequency distribution of external malformations in mutant mice with B6 background. (A) Otx2 heterozygous mutant N2 embryos (n=200) at 18.5 dpc obtained by backcrossing chimeras with wild-type B6 females are phenotypically classified into eight groups according to their external morphology. (B) Otx2 heterozygous mutant N3 embryos (n=200) at 18.5 dpc obtained by backcrossing the N2 male with wild-type B6 females are phenotypically classified into eight groups according to their external morphology.