Fig. 3. Variation of mandible length in Otx2 heterozygous mutant mice. Whole-mount views of skull morphology of wild type (A,B) and heterozygous mutant embryos (C-K) at 18.5 dpc following cartilage and bone staining. Mandibles have been separated in cases in which they were present (A-J). (K) An embryo lacking a mandible. The length of each mandible from proximal to distal is 5.4 mm (A), 5.4 mm (C), 4.2 mm (E), 2.8 mm (G) and 1.4 mm (I). an, angular process; as, alisphenoid; bs, basisphenoid; bo, basioccipital; cd, condyloid process; co, coronoid process; eo, exoccipital; mx, maxillar; pl, palatine; pm, premaxillar; sy, symphysis.