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Fig. 1. E17.5 Fog2–/– {alpha}MHC-Fog2 transgenic and normal mouse gonads. (A-C) Macroscopic view of the urogenital systems in male (A), female (B) and XY mutant (C) E17.5 fetuses. Mutant XY gonads are severely reduced in size and have not descended. a, adrenal, b, bladder, g, gonad, k, kidney. Only one paired organ is labeled. (D,E) Representative transverse sections through gonads at the same magnification of (D) normal testis and (E) Fog2–/– undifferentiated XY gonads (arrowhead). Notice the lack of testis cord development and greatly reduced size of mutant gonad.