Development -- Tevosian et al. 129 (19): 4627 Figure IG6

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Fig. 6. Whole-mount in situ hybridization analysis of Leydig cell markers (encoding steroidogenic enzymes) and the Wnt4 gene in E13.5-14.5 gonads. (A,C,E) Control gonads/mesonephroi; (B,D,F), Fog2^–/– gonads/mesonephroi. Steroidogenic genes are not expressed in the absence of Fog2 (B,D,F), indicating that Leydig cell differentiation is blocked. Wnt4 expression is downregulated in XY normal gonads (G), but persists in XX control (H) and XY Fog2^–/– gonads (I).