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Fig. 2. Sequence analysis of Lmo proteins from human, mouse and chicken sequences. (A) The non-mouse non-human expressed sequence tag (EST) database was searched with mouse amino acid sequences using the tBLASTn algorithm to identify cDNA sequences of chicken Lmo1 (GenBank Accession Number, AL587905) and Lmo2 (GenBank Accession Number, BI067394). Sequences are aligned to show the high degree of homology within Lmo family members of different species. Dots indicate missing sequence. (B) Sequence alignment of chicken Lmo1, Lmo2 and Lmo4 reveals high divergence overall; only three out of 13 amino acids are shared between Lmo1, Lmo2 and Lmo4 in the region (amino acids 145-157, underlined in red) used to make the Lmo4-specific c15 antibody. Lim1 and Lim2 domains are underlined in black.