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Fig. 1. Spectrum of head defects in Chrd-/-;Nog+/- neonates. External anatomy of (A) wild type, (B) single nostril (arrow) with narrow proboscis, (C) anterior truncation, (D) agnathia (arrow) with two distinct nostrils, (E) mid-face hypoplasia with loss of philtrum (arrow) and (F) bilateral cleft lip. Skeletal preparations of animals are shown of A-C: (A') wild type, (B') cebocephaly with cyclopic eye (arrow) beneath proboscis and (C') anterior truncation. Skeletal structures caudal to the head are normal. Scale bar: 2 mm.