Fig. 5. Dlx1/2 mutants show normal neurogenesis at E10.5, and begin to show elevations in Mash1, Hes5 and Dll1 expression by E11.5 in the SVZ. Coronal hemi-sections of control (left side) and Dlx1/2 mutant (right side) telencephalons at E10.5 (A-C') studied with immunofluorescence, and at E11.5 (D-F'), studied with radioactive in situ RNA hybridization. At E10.5 early neurons, assessed by expression of GABA and MAP2 (A,A',B,B') and radial glia, assessed by expression of RC2 (C,C'), appear normal in the Dlx1/2 mutants. At E11.5 expression of Mash1, Dll1 and Hes5 (D-F') increase in the SVZ (arrowheads). Scale bars: 100 µm.