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Fig. 8. Effects of fgf8 dysfunction on inner ear development. (A,B) Dorsal view of the hindbrain at 14 h showing expression of fgf3 (blue, with brackets) and krox20 (red) in ace/ace (A) and ace/ace; val/val (B) embryos. (C,D) Dorsolateral view showing pax5 expression in the otic vesicle at 24 h in ace/ace (C) and ace/ace; val/val (D) embryos. (E,F) Dorsolateral view showing anti-Pax2 staining in the otic vesicle at 30 h in ace/ace (E) and ace/ace; val/val (F) embryos. Relative positions of rhombomeres are indicated. Double mutants show ectopic expression of fgf3 in rX (B), ectopic expression of pax5 (D) and ectopic hair cells in the otic vesicle (F). Anterior is towards the left in all specimens. Scale bar: 80 µm in A,B; 30 µm in C-F.