Fig. 6. Regulation of dome expression by the JAK/STAT pathway. In hop mutant follicle cells, Dome protein level is up-regulated (A; Dome is in red). dome-GAL4 is a pGAL4 element inserted upstream to the dome transcription start site (E) that drives expression in BCs and posterior follicle cells (B). Overexpression of wild-type dome (C) strongly reduces the level of GFP driven by dome-GAL4 (compare B and C), while expression of domeEXT has no effect (D). In D, the reduction in GFP expression is due to the absence of BCs induced by the expression of domeEXT (see Fig. 5I). (E) Schematic view of the dome promoter showing the localization and sequence of 2 putative Stat92E binding sites.