Development -- Herbst et al. 129 (23): 5449 Figure IG5

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Fig. 5. AChR subunit genes are transcribed selectively in subsynaptic nuclei of Musk mutant mice expressing MCK-Musk and MCK-MMT. AChR ${alpha}$ and ${delta}$ mRNAs are expressed preferentially in the central, synaptic region of muscle (arrows) in wild-type mice and uniformly in skeletal muscle of Musk^-/- mice. In Musk^-/-; MCK-Musk and Musk^-/-; MCK-MMT mice, AChR ${alpha}$ and ${delta}$ mRNAs are expressed preferentially in the central region of the muscle. The pattern of AChR transcription was assessed by in situ hybridization of intercostal muscle from E18.5 embryos.