Fig. 3. Nested deficiencies of the posterior Hoxd complex, as produced by targeted meiotic recombination (TAMERE). At the top, the positions of the four regions (RIX to RXII) of high interspecies sequence conservation are show. The three deletions considered in this work are schematised below: Hoxd^del(13), a deletion of the Hoxd13 locus including RXI; Hoxd^del(13-12), a deletion of both Hoxd13 and Hoxd12 loci, including RXI and RX; and Hoxd^del(13-11), a deletion of all three Hoxd13 to Hoxd11 loci, including all conserved sequences but RXII. In each case, a loxP site (red triangle) is left upstream RXII, at the position of the 5' breakpoint of the deletions.