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Fig. 6. An inhibitor of FGFR1 tyrosine phosphorylation, SU5402, inhibits branching morphogenesis of E13 SMGs. (A) A time-course of SU5402 treatment reveals that at 20 hours (T20) the epithelial buds do not enlarge and cleft. The major duct continues to enlarge and undergo lumen formation (arrowhead). (B) Dose response of SU5402 treatment at 20 hours. The number of buds is expressed as a ratio of the number of buds at 20 hours/the number of buds at 2 hours (T20/T2).