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Fig. 2. Expression of mutant Xdsh elicits NT closure defects. (A,B) Control embryos at stage 22 have closed neural tubes. (C) An embryo expressing Xdd1 with an open neural tube. (D) Another embryo expressing Xdd1 with a milder open NT defect. NT is closed normally anterior and posterior to the NT defect. (E) An embryo expressing Xdsh-D2 displaying an NT defect. (E) Another Xdsh-D2 expressing embryo with a severe NT defect in which the entire length of the NT has failed to close.