Fig. 5. Failure of NT closure correlates with defective convergent extension of the embryo. (A) Individual images from time-lapse movies of neurulation showing control, closed-NT and open-NT embryos at stages 11.5, 14, 16, 18 and 22 (first panel shows vegetal view; all subsequent panels show dorsal view). (B) Plot of LWR of AP axis for control and Xdd1 closed-NT embryos. (C) Plot of LWR of AP axis for control and Xdd1 open-NT embryos. Data for B,C are mean LWR±s.d. (control n=16 embryos, eight movies; closed-NT n=10 embryos, six movies; open-NT n=22 embryos, seven movies; data points are for stages 10.5, 11, 12.5 and 13-20). (D) Rate of axis elongation (change in LWR/time) for control, closed-NT and open-NT embryos during early (white bars), middle (gray bars) and late neurulation (black bars). See also Movie 5 at http://dev.biologists.org/supplemental/