Fig. 2. Meis constructs. Meis3 deletion constructs (A) and fusions with Pbx4/Lzr (B) are shown schematically on the left. Columns on the right indicate whether each protein binds Pbx4/Lzr and displays activity in vivo. Asterisks indicate two constructs that have drastically reduced Pbx binding and in vivo activity, but retain some function (see text for details). na, not applicable [because the fusion constructs were designed not to require Pbx binding (see text for details)]. Meis3 is blue, except for the homeodomain (HD; white) and M1 and M2 (red). Yellow indicates sequences from the Prep1 C terminus that were inserted in place of the I domain in the CIMeis3 construct. The M1 and M2 domains in several fusion constructs (B) were mutated to abolish Pbx binding (purple). These domains are referred to as BM1 and BM2 in the text. Pbx4/Lzr is green.