Fig. 2. Ectopic Wg transduction in the wing, leg and eye upon simultaneous reduction of Apc1 and Apc2. (A-C) Constitutive activation of Wg transduction in the adult wing upon simultaneous reduction of Apc activity in Apc1^Q8 Apc2^d40 double mutant clones that are marked by a mutation in the yellow gene. Apc1^Q8 Apc2^d40 clones in anterior wing margin (arrowhead in A) form bristles (higher magnification shown in B), whereas in the posterior margin (arrow in A) form thin tapered hairs (higher magnification shown in C). Adult wing with mutant clones homozygous for Axin^S04423 (D,F) or zw3^M11-1 (E,G) show the same cell fate transformations, but only the Axin mutant clones are similar in size to those produced by Apc1^Q8 Apc2^d40. In the adult legs (H,I), marked Apc1^Q8 Apc2^d40 mutant clones are associated with outgrowths (arrow in H) and incomplete duplications (arrowhead in H) in regions containing dorsal and lateral pattern elements. In I, there is a duplication of a dorsal structure, the pre-apical bristle (arrow), and an incomplete distal duplication (double arrowhead), as well as a mutant clone of cells that includes the normally formed apical bristle, which is a ventral structure (single arrowhead). Constitutive activation of Wg transduction in the adult eye in an Apc1^Q8 Apc2^d40 mutant clone (J) or an Axin mutant clone (K) transforms ommatidial cells within the clone to cuticular fates.