Fig. 3. Abnormal extrahepatic biliary epithelium in the mutant mice. (A-C) Extrahepatic biliary tract of 2-month-old control (A) and mutant (B,C) mice. Mutant gallbladders are irregularly shaped. Some mutants show dilated cystic duct. gb, gallbladder; cd, cystic duct; bd, common bile duct; dd, duodenum. Scale bars: 5mm. (D-E) Gallbladder sections for control (D) and mutant (E) animals. In the mutant sample, the normal cuboidal epithelium is replaced in some areas by a stratified squamous epithelium (arrowhead) or mucus-secreting cells (arrow). lu, lumen. Scale bars: 100 µm in D; 150 µm in E.