Fig. 4. Morphological phenotypes of ptp-3 mutants. (A-D) Representative ptp-3(op147) mutant L1 stage larvae (grown at 25°C) showing defects in morphogenesis. The most common defect is a bulging or pinching of the posterior body (A); however, pinched or notched heads are also occasionally seen (B). Some inviable ptp-3(op147) larvae are starved, apparently a result of defects in pharyngeal morphogenesis (arrow in C). Some ptp-3(op147) larvae are deformed along the entire body (D). A wild-type L1 larva (E) and vab-1(null) mutant larva (F) showing the head morphology defect are shown for comparison. Scale bar, 13 µm (A-D), 20 µm (E,F).