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Fig. 1. Schematic of the SP-C/G6en and SP-C/en transgenic constructs. (A) The 3.7 kb human SP-C promoter/enhancer was used to drive expression of a fusion cDNA consisting of the DNA binding domain of mouse GATA6 (aa233-352) fused to the repression domain of the Drosophila Engrailed protein (aa1-298). This was followed by the SV40 poly(A)+ sequence. (B) The 3.7 kb human SP-C promoter/enhancer was also used to drive expression of the Drosophila Engrailed repression domain (aa1-298) containing a nuclear localization sequence at the amino-terminus (MKRKKK). This was followed by the SV40 poly(A)+ sequence.