Fig. 5. Cell proliferation in 5-day wounds. Mice were injected with BrdU 2 hours before sacrifice. Sections of 1-day (A,B) and 5-day (C,D) wounds from control mice (A,C) and K5ß1-null mice (B,D) were stained with an anti-BrdU antibody (stained nuclei are indicated by arrowheads and the epithelial wound edge by arrows in A,B). There was an obvious impairment of keratinocyte proliferation in the hair follicles of K5ß1-null mice (A-D; compare asterisks in A and B). G, granulation tissue; HE, hyperproliferative epithelium. Scale bars: 200 µm.